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TOPICAL tretinoin in animal teratogenicity exams has generated equivocal results. There is proof for teratogenicity (shortened or kinked tail) of topical tretinoin in Wistar rats at doses greater than one mg/kg/working day (forty two moments the maximum human systemic dose adjusted for overall human body surface area region).
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Tretinoin is surely an endogenous retinoid metabolite of Vitamin A that binds to intracellular receptors from the cytosol and nucleus, but cutaneous amounts of tretinoin in surplus of physiologic concentrations take place following software of the tretinoin-that contains topical drug products. Despite the fact that tretinoin activates a few users on the retinoic acid (RAR) nuclear receptors (RARα, RARβ, and RARγ) which can act to switch gene expression, subsequent protein synthesis, and epithelial cell development and differentiation, it has not been proven whether or not the clinical results of tretinoin are mediated by way of activation of retinoic acid receptors, other mechanisms such as irritation, or the two.